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葛紀(jì)彎
個(gè)人簡(jiǎn)介
葛紀(jì)彎,女,博士,助理教授,博士生導(dǎo)師。2013年獲山東大學(xué)學(xué)士學(xué)位,2019年獲清華大學(xué)理學(xué)博士學(xué)位,之后在清華大學(xué)從事博士后研究,期間獲2021年度清華大學(xué)優(yōu)秀博士后稱號(hào),北京市結(jié)構(gòu)生物學(xué)高精尖創(chuàng)新中心卓越學(xué)者。2023年以助理教授的身份加入中國(guó)醫(yī)學(xué)科學(xué)院病原生物學(xué)研究所。
研究方向
以結(jié)構(gòu)生物學(xué)為主要技術(shù)研究手段,包括冷凍電鏡、X射線晶體學(xué)等,輔以其他生物化學(xué)以及病毒學(xué)方法,探究重要病原的入侵以及病原與宿主相互作用的分子機(jī)制。
科研項(xiàng)目
主持中國(guó)醫(yī)學(xué)科學(xué)院中央級(jí)公益性科研院所基本科研業(yè)務(wù)費(fèi)
主持中國(guó)博士后科學(xué)基金面上項(xiàng)目
主持國(guó)家自然科學(xué)基金青年項(xiàng)目
研究成果
迄今以(共同)第一作者/通訊作者身份在Nature、Immunity、Nature Communications、Cell Research, Structure等雜志發(fā)表高水平論文10篇:
1. Lan J, Chen P, Liu W, Ren W, Zhang L, Ding Q, Zhang Q, Wang X, Ge J. Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2. Structure. 2022 Oct 6;30(10):1432-1442.e4. doi: 10.1016/j.str.2022.07.005. (共同通訊作者)
2. Qiao S, Zhang S, Ge J, Wang X. The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition. FEBS Open Bio. 2022 Sep;12(9):1602-1622. doi: 10.1002/2211-5463.13454. (共同通訊作者)
3. Lan J, He X, Ren Y, Wang Z, Zhou H, Fan S, Zhu C, Liu D, Shao B, Liu TY, Wang Q, Zhang L, Ge J, Wang T, Wang X. Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell Research. 2022 Jun;32(6):593-595. doi: 10.1038/s41422-022-00644-8.(共同通訊作者)
4. Wang R, Zhang Q, Ge J, Ren W, Zhang R, Lan J, Ju B, Su B, Yu F, Chen P, Liao H, Feng Y, Li X, Shi X, Zhang Z, Zhang F, Ding Q, Zhang T, Wang X, Zhang L. Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity. 2021 Jul 13;54(7):1611-1621.e5. doi: 10.1016/j.immuni.2021.06.003. (共同第一作者)
5. Zhang Q, Ju B, Ge J, Chan JF, Cheng L, Wang R, Huang W, Fang M, Chen P, Zhou B, Song S, Shan S, Yan B, Zhang S, Ge X, Yu J, Zhao J, Wang H, Liu L, Lv Q, Fu L, Shi X, Yuen KY, Liu L, Wang Y, Chen Z, Zhang L, Wang X, Zhang Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nature Communications 2021 Jul 9;12(1):4210. doi: 10.1038/s41467-021-24514-w. (共同第一作者)
6. Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z, Wang X, Zhang L. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications 2021 Jan 11;12(1):250. doi: 10.1038/s41467-020-20501-9. (共同第一作者)
7. Ge J, Zhang S, Zhang L, Wang X. Structural basis of severe acute respiratory syndrome coronavirus 2 infection. Curr Opin HIV AIDS. 2021 Jan;16(1):74-81. doi: 10.1097/COH.0000000000000658. (第一作者)
8. Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature. 2020 Aug;584(7819):115-119. doi: 10.1038/s41586-020-2380-z. (共同第一作者)
9. Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020 May;581(7807):215-220. doi: 10.1038/s41586-020-2180-5. (共同第一作者)
10. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X. Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure. 2019 Aug 6;27(8):1296-1307.e5. doi: 10.1016/j.str.2019.05.011. (共同第一作者)
研究生培養(yǎng)
目前課題組在讀博士生一名,研究生一名。