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中國(guó)醫(yī)學(xué)科學(xué)院副院長(zhǎng)、北京協(xié)和醫(yī)學(xué)院副校長(zhǎng)，系統(tǒng)醫(yī)學(xué)研究院院長(zhǎng)/蘇州系統(tǒng)醫(yī)學(xué)研究所所長(zhǎng)，中法新發(fā)病原體聯(lián)合實(shí)驗(yàn)室主任。中國(guó)醫(yī)學(xué)科學(xué)院學(xué)部委員。
 國(guó)家杰出青年科學(xué)基金獲得者、教育部長(zhǎng)江學(xué)者特聘教授、國(guó)家“萬(wàn)人計(jì)劃”首批科技創(chuàng)新領(lǐng)軍人才、國(guó)家自然科學(xué)基金委創(chuàng)新研究群體負(fù)責(zé)人、教育部創(chuàng)新團(tuán)隊(duì)帶頭人，榮獲全國(guó)優(yōu)秀科技工作者、全國(guó)科技系統(tǒng)抗擊新冠疫情先進(jìn)個(gè)人、第三屆全國(guó)創(chuàng)新?tīng)?zhēng)先獎(jiǎng)狀、第二十三屆吳階平-保羅·楊森醫(yī)學(xué)藥學(xué)獎(jiǎng)等多項(xiàng)榮譽(yù)。
  “十三五”計(jì)劃“艾滋病和病毒性肝炎等重大傳染病防治”科技重大專項(xiàng)總體組成員、國(guó)家“生物安全關(guān)鍵技術(shù)研發(fā)”重點(diǎn)專項(xiàng)專家組成員。“十四五”“病原學(xué)與防疫技術(shù)”“生物大分子與微生物組”“生物安全關(guān)鍵技術(shù)研發(fā)”以及科技基礎(chǔ)資源調(diào)查等國(guó)家重點(diǎn)專項(xiàng)專家組成員。國(guó)務(wù)院第八屆學(xué)科評(píng)議組成員。北京市第七屆自然科學(xué)基金委員會(huì)委員。教育部病毒學(xué)領(lǐng)域知識(shí)體系建設(shè)專家組組長(zhǎng)。中華預(yù)防醫(yī)學(xué)會(huì)第六屆理事會(huì)常務(wù)理事兼生物信息學(xué)分會(huì)主任委員，中華醫(yī)學(xué)會(huì)第二十六屆理事會(huì)常務(wù)理事兼醫(yī)學(xué)病毒學(xué)分會(huì)副主任委員，上海證券交易所第二屆科技創(chuàng)新咨詢委員會(huì)委員。Biosafety & Health雜志執(zhí)行主編，F(xiàn)rontiers in Microbiology、Chin Med J、《中華微生物與免疫學(xué)雜志》副主編。
先后承擔(dān)國(guó)家863計(jì)劃、973計(jì)劃、科技重大專項(xiàng)、國(guó)家自然科學(xué)基金等科研項(xiàng)目10余項(xiàng)。作為通訊作者（共同通訊作者）在Cell、Lancet、Lancet Microbe、Cell Host Microbe、Lancet Resp Med、Am J Resp Crit Care Med、Cell Res、PNAS 等雜志發(fā)表SCI論文160余篇，被引用逾8.3萬(wàn)次（Google Scholar數(shù)據(jù)），被多部國(guó)際指南、國(guó)際專利和國(guó)際政策文件參引。2020-2022年度連續(xù)入選愛(ài)思唯爾中國(guó)高被引學(xué)者榜單，2022年度入選科睿唯安全球高被引科學(xué)家以及斯坦福大學(xué)全球前2%頂尖科學(xué)家榜單。
獲省部級(jí)及以上科技獎(jiǎng)勵(lì)7項(xiàng)。研究成果入選“中國(guó)2020年度生命科學(xué)十大進(jìn)展”、2020年度“中國(guó)十大醫(yī)學(xué)科技新聞”、2020年度“十大醫(yī)學(xué)進(jìn)展”、“中國(guó)2020年度重要醫(yī)學(xué)進(jìn)展”（3項(xiàng)）、“中國(guó)2021年度重要醫(yī)學(xué)進(jìn)展”（2項(xiàng)）、“中國(guó)2022年度重要醫(yī)學(xué)進(jìn)展”（1項(xiàng)）、2020年Springer Nature中國(guó)學(xué)者年度高影響力研究。5篇論文入選2020、2021年度中國(guó)百篇最具影響國(guó)際學(xué)術(shù)論文。

呼吸道病毒感染致病機(jī)制及干預(yù)研究

1.    醫(yī)學(xué)病毒學(xué)“醫(yī)學(xué)病毒學(xué)（病毒變異與感染致病機(jī)制）”，國(guó)家自然基金委創(chuàng)新研究群體項(xiàng)目（82221004），2023.01~2027.12，1000萬(wàn)元，項(xiàng)目負(fù)責(zé)人
2.    “重要腸道病毒感染復(fù)制關(guān)鍵宿主因子全景式篩選及其作用分子機(jī)制研究”，國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（81930063），2020.01~2024.12，297萬(wàn)元，項(xiàng)目負(fù)責(zé)人
3.    “重要新發(fā)突發(fā)傳染病生物安全基礎(chǔ)與防控技術(shù)研究”，醫(yī)學(xué)與健康科技創(chuàng)新工程項(xiàng)目，2016.10~2020.12，1100萬(wàn)元，首席專家
4.    國(guó)際合作項(xiàng)目“新發(fā)病原體研究”， 2022.4~2027.3，150萬(wàn)歐元，項(xiàng)目負(fù)責(zé)人

（一）代表性論文 
以通訊作者（含共同）身份發(fā)表論文約160余篇，代表性論文【# first authors,*corresponding author】：
1.    Zhang D#, Qiao L#, Lei X#, Dong X, Tong Y, Wang J*, Wang Z*, Zhou R*. Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein. Nat Commun. 2023 Jun 22; 14(1): 3715.
2.    Guo L#, Zhang Q#, Zhang C, Huang T, Ren L, Cao B*, Wang J*. Assessment of Antibody and T-Cell Responses to the SARS-CoV-2 Virus and Omicron Variant in Unvaccinated Individuals Recovered From COVID-19 Infection in Wuhan, China. JAMA Network Open. 2022 Apr 1;5(4): e229199.
3.    Guo S#, Lei X#, Chang Y#, Zhao J#, Wang J#, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F*, Wang J*, Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400.
4.    Zhang S#, Huang W#, Ren L#, Ju X#, Gong M#, Rao J#, Sun L, Li P, Ding Q*, Wang J*, Zhang QC*. Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2. Cell Res. 2022 Jan; 32(1):9-23.
5.    Wu Z, Jin Q, Wu G, Lu J, Li M, Guo D, Lan K, Feng L, Qian Z, Ren L, Tan W, Xu W, Yang W, Wang J*, Wang C. SARS-CoV-2's origin should be investigated world wide for pandemic prevention. Lancet. 2021 Oct 9;398(10308):1299-1303. 
6.     Huang L#, Yao Q#, Gu X#, Wang Q#, Ren L#, Wang Y#, Hu P#, Guo L#, Liu M, Xu J, Zhang X, Qu Y, Fan Y, Li X, Li C, Yu T, Xia J, Wei M, Chen L, Li Y, Xiao F, Liu D, Wang J*, Wang X*, Cao B*. 1-year outcomes in hospital survivors with COVID-19: alongitudinal cohort study. Lancet. 2021 Aug 28;398(10302):747-758. 
7.    Liu X#, Xu F#, Ren L#, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J*, Guo F*. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nat Commun. 2021 Jul 20;12(1):4427.
8.    Cao C#, Cai Z#, Xiao X#, Rao J, Chen J, Hu N, Yang M, Xing X, Wang Y, Li M, Zhou B, Wang X, Wang J*, Xue Y*. The architecture of the SARS-CoV-2 RNA genome inside virion. Nat Commun. 2021 Jun 24;12(1):3917.
9.    He Z#, Ren L#, Yang J#, Guo L#, Feng L#, Ma C, Wang X, Leng Z, Tong X, Zhou W, Wang G, Zhang T, Guo Y, Wu C, Wang Q, Liu M, Wang C, Jia M, Hu X, Wang Y, Zhang X, Hu R, Zhong J, Yang J, Dai J, Chen L, Zhou X, Wang J*, Yang W*, Wang C*. Seroprevalence and humoral immune durability ofanti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study. Lancet. 2021 Mar 20;397(10279):1075-1084.
10.    Sun L#, Li P#, Ju X#, Rao J#, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q*, Wang J*, Zhang QC*. In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs. Cell. 2021 Feb 9: S0092-8674(21)00158-6.
11.    Zhang C#, Li W#, Lei X, Xie Z, Qi L, Wang H, Xiao X, Xiao J, Zheng Y, Dong C, Zheng X, Chen S, Chen J, Sun B, Qin J, Zhai Q, Li J, Wei B*, Wang J*, Wang H*. Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity. Sci Adv. 2021 Sep 17;7(38): eabb5933.
12.    Zhang T#, Yang Y#, Xiang Z#, Gao CC#, Wang W, Wang C, Xiao X, Wang X, Qiu WN, Li WJ, Ren L, Li M, Zhao YL, Chen YS*, Wang J*, Yang YG*. N6-methyladenosine regulates RNA abundance of SARS-CoV-2. Cell Discov. 2021 Jan 28;7(1):7.
13.    Zhu Y#, Yu D#, Han Y#, Yan H, Chong H, Ren L, Wang J*, Li T*, He Y*. Cross-reactive neutralization of SARS-CoV-2 by serum antibodies from recovered SARS patients and immunized animals. Sci Adv. 2020 Nov 6;6(45): eabc9999.
14.    Huang C#, Huang L#, Wang Y#, Li X#, Ren L#, Gu X#, Kang L#, Guo L#, Liu M#, Zhou X, Luo J, Huang Z, Tu S, Zhao Y, Chen L, Xu D, Li Y, Li C, Peng L, Li Y, Xie W, Cui D, Shang L, Fan G, Xu J, Wang G, Wang Y, Zhong J, Wang C, Wang J*, Zhang D*, Cao B*. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2023 Jun 17;401(10393): e21-e33.
15.    Chi X#, Liu X#, Wang C#, Zhang X, Li X, Hou J, Ren L, Jin Q*, Wang J*, Yang W*. Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain. Nat Commun. 2020 Sep 10;11(1):4528.
16.    Lei X#, Dong X#, Ma R#, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z*, Xiang Z*, Wang J*. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun. 2020, 2020 Jul 30;11(1):3810.
17.    Han Z#, Rao J#, Xie Z#, Wang C, Xu B, Qian S, Wang Y, Zhu J, Yang B, Xu F, Lei X, Guo F, Zhao Z, Ren L*, Wang J*. Chemokine (C-X-C motif) Ligand 4 is a Restrictor of Respiratory Syncytial Virus Infection and an Indicator of Clinical Severity. Am J Respir Crit Care Med. 2020 Sep 1;202(5):717-729.
18.    Ou X#, Liu Y#, Lei X#, Li P, Mi D, Ren L, Guo L, Guo R, Chen T, Hu J, Xiang Z, Mu Z, Chen X, Chen J, Hu K, Jin Q*，Wang J*，Qian Z. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nature Commun. 2020, 11:1620.
19.    Pang X#, Ren L#, Wu S#, Ma W#, Yang J, Di L, Li J, Xiao Y, Kang L, Du S, Du J, Wang J, Li G, Zhai S, Chen L, Zhou W, Lai S, Gao L, Pan Y*, Wang Q*, Li M*, Wang J*, Huang Y*, Wang J*, COVID-19 Field Response Group, COVID-19 Laboratory Testing Group. Cold-chain food contamination as the possible origin of Covid-19 resurgence in Beijing.  Natl Sci Rev. 2020, 7(12), 1861–1864.
20.    Guo L#, Ren L#, Yang S#, Xiao M#, Chang D#, Yang F#, Dela Cruz C，Wang Y, Wu C，Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang Q, Xu S, Zhu H, Xu Y, Jin Q, Sharma L*, Wang L*, Wang J*. Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Clin Infect Dis. 2020 Jul 28;7 1(15):778-785.
21.    Huang C#, Wang Y#, Li X#, Ren L#, Zhao J#, Hu Y#, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q，Wang J*, Cao B*. Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China. Lancet. 2020，395(10223), 497-506.
22.    Ren L#, Wang Y, Wu ZQ#, Xiang Z#, Guo L#, Xu T#, Jiang Y#, Xiong Y#, Li Y, Li X, Li H, Fan GH, Gu X Xiao Y, Gao H, Xu J, Yang F, Wang X, Wu C, Chen L, Liu Y, Liu B, Yang J, Wang X, Dong J, Li L, Huang C, Zhao J, Hu Y, Cheng Z, Liu L, Qian Z, Qin C*, Jin Q*, Cao B*, Wang J*. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl).2020.133(9):1015-1024.
23.    Zhou Z#, Ren L#, Zhang L#, Zhong J#, Xiao Y#, Jia Z, Guo L, Yang J, Wang C, Jiang S, Yang D, Zhang G, Li H, Chen F, Xu Y, Chen M, Gao Z, Yang J, Dong J, Liu B, Zhang X, Wang W, He K, Jin Q, Li M*, Wang J*. Heightened innate immune response in COVID-19 cases. Cell Host Microbe. 2020, 27(6):883-890.e2.
24.    Wang C, Zhai X, Zhang X, Li L, Wang J*, Liu DP. Gene-edited babies: Chinese Academy of Medical Sciences' response and action. Lancet. 2019, 393(10166):25-26.
25.    Wang H#, Lei X#, Xiao X, Yang C, Lu W, Huang Z, Leng Q, Jin Q, He B, Meng G*, Wang J*. Reciprocal regulation between enterovirus 71 and the NLRP3 inflammasome. Cell Rep. 2015; 12：85.
26.    Lei X, Cui S, Zhao Z*, Wang J*. Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease. Natnl Science Rev, 2015,2 (3): 268-284 doi:10.1093 /nsr/nwv038 (Review)
27.    Zhou Z, Jia X, Xue Q, Dou Z, Ma Y, Zhao Z, Jiang Z, He B, Jin Q*, Wang J*. TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci U S A, 2014, 111(2): E245-254. 
28.    Zhou Z, Cao M, Guo Y, Zhao L, Wang J,Jia X, Li J, Wang C, Gabriel G, Xue Q, Yi Y, Cui S, Jin Q*, Wang J*,Deng T*. Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus. Nat Commun, 2014, 5: 32-59. (IF 16.6)

（二）科技獎(jiǎng)勵(lì)
1. 洪濤，王健偉. 戰(zhàn)勝瘟疫. 2003年第五屆全國(guó)優(yōu)秀科普作品圖書(shū)類三等獎(jiǎng).
2. 秦川，魏強(qiáng)，王健偉，等. SARS冠狀病毒感染恒河猴等動(dòng)物的模型建立. 2004年北京市科學(xué)技術(shù)獎(jiǎng)二等獎(jiǎng).
3. 秦川，魏強(qiáng)，王健偉，等. 動(dòng)物生物安全實(shí)驗(yàn)室保障技術(shù)平臺(tái)的建立. 2012年中國(guó)實(shí)驗(yàn)動(dòng)物學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng).
4. 王健偉、許文波等. 重要和新發(fā)現(xiàn)呼吸道病毒的病原學(xué)研究及其應(yīng)用. 2015年中華預(yù)防醫(yī)學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng)，一等獎(jiǎng).
5. 王健偉, 任麗麗, 等. 重要和新發(fā)現(xiàn)呼吸道及腸道病毒的病原學(xué)研究及其應(yīng)用. 2015年度高等學(xué)?？茖W(xué)研究?jī)?yōu)秀成果獎(jiǎng)（科學(xué)技術(shù)）二等獎(jiǎng).
6. 黃芳，王健偉，等. 北京呼吸道傳染病病原體流行變異規(guī)律研究及其應(yīng)用. 2019年度北京市科學(xué)技術(shù)進(jìn)步獎(jiǎng)二等獎(jiǎng)

團(tuán)隊(duì)累計(jì)培養(yǎng)研究生、博士后100余人次