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雷曉波
個(gè)人簡(jiǎn)介
中國(guó)醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院病原生物學(xué)研究所研究員，博士生導(dǎo)師。主要從事呼吸道病毒與宿主相互作用機(jī)制及其感染致病機(jī)制的研究。主持國(guó)家傳染病重大專項(xiàng)和國(guó)家自然科學(xué)基金面上項(xiàng)目等多項(xiàng)國(guó)家級(jí)科研項(xiàng)目。在Nat Commun、Signal Transduct Target Ther、Cell Rep、PLoS Pathog、J Biol Chem、J Virol、Natl Sci Rev和FASEB J等SCI收錄雜志上發(fā)表SCI論文24篇。入選2020年Springer Nature中國(guó)學(xué)者年度高影響力研究，2022年斯坦福大學(xué)全球前2%頂尖科學(xué)家榜單。目前擔(dān)任中國(guó)微生物學(xué)會(huì)病毒學(xué)專業(yè)委員會(huì)委員和中華預(yù)防醫(yī)學(xué)會(huì)醫(yī)學(xué)病毒學(xué)分會(huì)青年小組委員。
研究方向
重要呼吸道病毒與宿主相互作用研究
科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目，GSDME介導(dǎo)的細(xì)胞焦亡在腸道病毒71型感染致病機(jī)制中的作用研究，81971948，課題負(fù)責(zé)人；
2. 國(guó)家傳染病重大專項(xiàng)，基于人類全基因組編碼及非編碼區(qū)高通量篩選的抗病毒靶標(biāo)發(fā)現(xiàn)新技術(shù)研究，ZX201810301401，課題負(fù)責(zé)人；
3. 國(guó)家自然科學(xué)基金面上項(xiàng)目，高爾基體ACBD3蛋白復(fù)合物參與EV71復(fù)制的分子機(jī)制研究，81672032，課題負(fù)責(zé)人；
4. 中國(guó)醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與健康科技創(chuàng)新工程，抗感染藥物/疫苗快速評(píng)測(cè)與開(kāi)發(fā)，2016-I2M-1-005，子課題負(fù)責(zé)人；
5. 國(guó)家重點(diǎn)研發(fā)計(jì)劃，新型冠狀病毒感染復(fù)制關(guān)鍵宿主因子及其作用機(jī)制研究，2020YFA0707600，課題骨干；
6. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，重要腸道病毒感染復(fù)制關(guān)鍵宿主因子全景式篩選及其作用分子機(jī)制研究，81930063，2020.01-2024.12，課題骨干。
研究成果
代表性論文：(# 共同第一作者；* 共同通訊作者)
1. Zhang D#, Qiao L#, Lei X#, Dong X, Tong Y, Wang J*, Wang Z*, Zhou R*. Mutagenesis and structural studies reveal the basis for the specific binding of SARS- CoV-2 SL3 RNA element with human TIA1 protein. Nat Commun. 2023 Jun 22; 14(1):3715.
2. Wu Z#, Lei X#, Wang X#, Zhang Z, Li Y, Gao L, Liang X, Wang P, Wang J*, Ma C*. Peptide targeting the interaction of S protein cysteine-rich domain with Ezrin restricts pan-coronavirus infection. Signal Transduct Target Ther. 2023 Jan 18;8(1):19.
3. Guo S#, Lei X#, Chang Y#, Zhao J#, Wang J#, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F*, Wang J*, Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400.
4. Dong S#, Shi Y#, Dong X, Xiao X, Qi J, Ren L, Xiang Z, Zhou Z, Wang J*, Lei X*. Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection. J Biol Chem. 2022 May; 298(5): 101850.
5. Zhou Z#, Zhang X#, Lei X#, Xiao X#, Jiao T, Ma R, Dong X, Jiang Q, Wang W, Shi Y, Zheng T, Rao J, Xiang Z, Ren L, Deng T, Jiang Z, Dou Z, Wei W*, Wang J*. Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Signal Transduct Target Ther. 2021 Nov 3; 6(1):382.
6. Wang W#, Zhou Z#, Xiao X#, Tian Z, Dong X, Wang C, Li L, Ren L, Lei X*, Xiang Z*, Wang J*. SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation. Cell Mol Immunol. 2021,18(4):945-953.
7. Lei X#, Dong X#, Ma R#, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z*, Xiang Z*, Wang J*. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun, 2020, 11(1): 3810.
8. Lei X#, Zhang Z#, Xiao X, Qi J, He B*, Wang J*. Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D. J Virol. 2017, 91(18): e01069-17.
9. Xiao X#, Lei X#, Zhang Z, Ma Y, Qi J,Wu C, Xiao Y, Li L, He B*, Wang J*. Enterovirus 3A facilitates viral replication by promoting Phosphatidylinositol4-kinaseIIIβ-ACBD3 interaction. J Virol. 2017, 91(19): e00791-17.
10. Wang H#, Lei X#, Xiao X, Yang C, Lu W, Huang Z, Leng Q, Jin Q, He B, Meng G*, Wang J*. Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. Cell Rep. 2015, 12(1): 42-48.
11. Lei X#, Cui Sheng, Zhao Z*, Wang J*. Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease. Natl Sci Rev. 2015, 2 (3): 268-284.
12. Lei X#, Han N#, Xiao X, Jin Q*, He B*, Wang J*. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. J Virol. 2014, 88(17): 9830-9841.
13. Lei X, Xiao X，Xue Q，Jin Q*, He B*, Wang J*. Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses. J Virol. 2013，87（3）：1690-1698.
14. Lei X#, Sun Z#, Liu X, Jin Q*, He B*, Wang J*.Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3，J Virol. 2011，85（17）：8811-8818.
15. Lei X, Liu X, Ma Y, Sun Z, Yang Y, Jin Q*, He B*, Wang J*. The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol. 2010, 84(16): 8051-8061.
研究生培養(yǎng)
團(tuán)隊(duì)累計(jì)培養(yǎng)研究生、博士后10人次